Kit for isolation of stromal-vascular fraction from adipose tissue for use in regenerative medicine

Cell technologies

Project objective

Development of a medical device for the treatment of adipose tissue in order to obtain stromal-vascular fraction.

Introduction of this medical device on the Russian and world markets.

Project description

Within the framework of the project, a line of medical products for the isolation of autologous stromal-vascular fraction from human adipose tissue is being developed.

The line includes:

  • disposable sterile kit including a device for separation of cellular fractions and an enzyme for the treatment of tissue;
  • other related products for the treatment of adipose tissue.

Application areas

  • Treatment of various skin defects:
    • Postoperative scars;
    • Scars;
    • Age change;
  • Treatment of alopecia;
  • Treatment of skin pigmentation
  • Treatment of various skin lesions (burns, trophic ulcers);
  • Treatment of diseases of the urogenital sphere (erectile dysfunction, strictures of the urethra, stress urinary incontinence, anatomical deformities);
  • Restoration of damaged ligaments and articular cartilage (tears, fractures, osteoarthritis, etc.);
  • Technologies for increasing the effectiveness of traditional treatment regimens, improving the quality of life and revitalization;
  • Application in tissue engineering;
  • Restoration of the jawbone with its thinning and the impossibility of installing implants;
  • Correction of post-traumatic soft tissue defects

Benefits of the project

The developed medical device has a number of advantages:

  • convenience and ease of use;
  • low cost;
  • quality and safety of the resulting material ensured by specialized protocol of adipose tissue treatment.

Patents/licenses/certificates

Patent of the Russian Federation No. 2620304 of 03.11.2015 "A device for separation of cell fractions from human and animal tissues and the method of using it"

Application WO 2017/078563 A1 of 03.11.2015 "A device for separation of cell fractions from human and animal tissues and the method of using it"

Patent of the Russian Federation No. 173796 of 03.03.2017 "A device for fractionation of adipose tissue and isolation of stromal-vascular fraction from it for use in regenerative medicine"

Application WO 2018/160096 A1 A1 of 29.09. 2017 "A device for fractionation of adipose tissue and isolation of stromal-vascular fraction from it for use in regenerative medicine"

Certificate ISO 9001: 2015 (GOST ISO 9001-2015) No. ROSS RU.OS / 07.SMKE.18-0431

Certificate of conformity ISO 13485:2003 (GOST ISO 13485-2011) No. ROSS RU.OS / 07.SMKE.18-0002

Publications

  1. Veremeev A.V., Bolgarin R.N., Petkova M. A., Katz N.D., Nesterenko V.G. "Stromal vascular fraction of adipose tissue as an alternative source of cellular material for regenerative medicine" Genes & Cells: Volume XI, No. 1, 2016, pp. 35-42
  2. Veremeev A., Katz N. , Bolgarin R., Petkova M., Kornienko I., Melerzanov A., Manturov N., Nesterenko V. "Semi-automatic system for isolation of stromal-vascular fraction of adipose tissue" Journal DOCTOR, January 2017, pp. 68-72
  3. Results presented at the 2nd national Congress on Regenerative Medicine (Moscow, 3-5 December 2015): Veremeev A.V., Petkova M. A., Gretzov E.M., Bolgarin R.N., Katz N. D. "Characteristics of stromal vascular fraction of adipose tissue isolated with the use of the "miniSTEM" system" 2nd national Congress on Regenerative Medicine: Proceedings of the 2nd Congress - M., 2015. - p. 40.

Project is supported by

  • Skolkovo Fund
    Skolkovo Fund
  • Kaluga Pharmaceutical Cluster
    Kaluga Pharmaceutical Cluster

Project status

Registration of the medical product in RF
Production scaling